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THE CLINICAL PROBLEM Early tolerability drives adherence Starting antidepressants at lower doses and increasing gradually improves tolerability and helps patients stay on treatment long enough to benefit

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Also, autaptic hippocampal cultures produced from these transgenic mice showed a decrease in both amplitude and frequency of EPSCs, whilst neurons of Mecp2 Tg1 mice, with an upregulated Mecp2 gene, had an opposite effect [377]